While at the Hilton attached to the convention center in downtown San Jose, California, I saw a distant view of the Lick Observatory on snow-covered Mt. Hamilton (23 March 2009).
The leftmost dome is the Shane 3 meter, while the rightmost dome is the 0.9 meter refractor.
Of course if one can see Lick from San Jose, the city is also visible from the mountain, and light pollution is a real problem.